aFGF, Endogenous Satiety Substance, Facilitates Learning, Memory and Immune Function in Aging

摘要: aFGF injection s.c. once a week into SAMP8 was begun at 3 weeks after birth and continued for 10 months. Saline injected as control. learning memory cellular immunological functions in the group were enhanced significantly, while those of saline deteriorated. 1. The number cholinergic neurons decreased by less than 20% ChAT activity individual medial septum which send monosyonaptic terminals to hippocampus significantly group, but not so much group. 2. respective densities muscarinic receptors, on hippocampal higher 3. LTP slice preparations facilitated 4. DTH, (T cell immune response) measured end 2nd 7th months reduced month compared with protected against this reduction. 5. These results show that provides protection impairment only also DTH immunoreactivity SAMP8.