Pharmaceutical Applications of NMR

摘要: Publisher Summary Nuclear magnetic resonance (NMR) spectroscopy plays an important role in the pharmaceutical sciences. This chapter focuses on applications of NMR. Some NMR methods used drug design and selected to specific classes bioactive molecules are described chapter. Applications had determination structures conformations biologically organic molecules. The development methodology for assigning determining peptides proteins by two-dimensional (2D) has enabled a wide range new field design. instruments examine samples ranging complexity from solutions molecules, their receptor proteins, intact organs animals. Three experiments can be identified-small-molecule NMR, macromolecular vivo Small-molecule contributes both as analytical tool verification structure synthesized at stage. Macromolecular assist receptor-based providing key protein targets, is also extremely valuable vitro testing techniques conformations, determination, protein–ligand complexes. studies characterizing dynamic nature insulin solution, consequently have provided some insight into binding.