The effect of alpha-tocopherol on the lipid peroxidation of mitochondria and microsomes obtained from rat liver and testis.
作者： Mariana Gavazza , Angel Catalá
关键词:
摘要: The effect of intraperitoneal administration α‐tocopherol (100 mg/kg wt/24 h) on ascorbate (0.4 mM) induced lipid peroxidation mitochondria and microsomes isolated from rat liver testis was studied. Special attention paid to the changes produced highly polyunsaturated fatty acids C20:4 n6 C22:6 n3 in C22:5 testis. or a significant decrease control group, whereas acid composition treated group were not observed. light emission significantly higher than group. , n3, these observed mitochondria. both groups similar. treatment with at dose times indicated showed protector mitochondria, those situated protected during non enzymatic ascorbate‐Fe2+ peroxidation. by but could be explained if we consider that sum + is 2-fold present
springer.com
sci-hub.se 参考文章(18)
J. G. Coniglio, A. R. Whorton, J. K. Beckman, Essential Fatty Acids in Testes Function and Biosynthesis of Lipids. ,vol. 83, pp. 575- 589 ,(1977) , 10.1007/978-1-4684-3276-3_52
Rosana Zanetti, Angel Catalá, Ascorbate-Fe2+ lipid-peroxidation of rat liver microsomes: effect of vitamin E and cytosolic proteins. Molecular and Cellular Biochemistry. ,vol. 183, pp. 49- 54 ,(1998) , 10.1023/A:1006843932049
George O. Burr, Mildred M. Burr, A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET Journal of Biological Chemistry. ,vol. 82, pp. 345- 367 ,(1929) , 10.1016/S0021-9258(20)78281-5
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Kjetil Retterstøl, Trine B. Haugen, Berit Woldseth, Bjørn O. Christophersen, A comparative study of the metabolism of n-9, n-6 and n-3 fatty acids in testicular cells from immature rat. Biochimica et Biophysica Acta. ,vol. 1392, pp. 59- 72 ,(1998) , 10.1016/S0005-2760(98)00021-6
P B McCay, Vitamin E: Interactions with Free Radicals and Ascorbate Annual Review of Nutrition. ,vol. 5, pp. 323- 340 ,(1985) , 10.1146/ANNUREV.NU.05.070185.001543
B Halliwell, FREE RADICALS, ANTIOXIDANTS AND HUMAN DISEASE: CURIOSITY, CAUSE, OR CONSEQUENCE The Lancet. ,vol. 344, pp. 721- 724 ,(1994) , 10.1016/S0140-6736(94)92211-X
J.R. Wright, R.C. Rumbaugh, H.D. Colby, P.R. Miles, The relationship between chemiluminescence and lipid peroxidation in rat hepatic microsomes Archives of Biochemistry and Biophysics. ,vol. 192, pp. 344- 351 ,(1979) , 10.1016/0003-9861(79)90102-4
G.A.A. Kivits, M.A.C.R. Ganguli-Swarttouw, E.J. Christ, The composition of alkanes in exhaled air of rats as a result of lipid peroxidation in vivo Effects of dietary fatty acids, vitamin E and selenium Biochimica et Biophysica Acta. ,vol. 665, pp. 559- 570 ,(1981) , 10.1016/0005-2760(81)90271-X
Feng Qin Yin, Qi Chen, Howard Sprecher, A comparison of the metabolism of [3-14C]-labeled 22- and 24-carbon (n-3) and (n-6) unsaturated fatty acids by rat testes and liver. Biochimica et Biophysica Acta. ,vol. 1438, pp. 63- 72 ,(1999) , 10.1016/S1388-1981(99)00039-6