A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial.

摘要: Polydrug use is common, and might occur because certain individuals experience positive effects from several different drugs during early stages of use. This study examined individual differences in subjective responses to single oral doses d-amphetamine, alcohol, delta-9-tetrahydrocannabinol (THC) healthy social drinkers. Each these produces feelings well-being at least some individuals, we hypothesized that would be positively correlated. We also participants' drug relation personality traits associated with In this initial, exploratory study, 24 healthy, light users (12 male, 12 female), aged 21-31 years, participated a fully within-subject, randomized, counterbalanced design six 5.5-hour sessions which they received d-amphetamine (20mg), alcohol (0.8 g/kg), or THC (7.5 mg), each paired placebo session. Participants rated the drugs' on both global measures (e.g. feeling effect all) drug-specific measures. general, three were unrelated. Unexpectedly, "wanting more" was inversely correlated THC. Additionally, women, but not men, "disliking" negatively Positive amphetamine related, only who experienced stimulant alcohol. Finally, high trait constraint (or lack impulsivity) lower reports liking No predicted across multiple types. Generally, findings do support idea greater classes, instead provide evidence for "drug choice" model, respond classes share similar effects, dislike other types drugs.