Transition-metal-free and chemoselective NaO(t)Bu-O2-mediated oxidative cleavage reactions of vic-1,2-diols to carboxylic acids and mechanistic insight into the reaction pathways.
作者： Sun Min Kim , Dong Wan Kim , Jung Woon Yang
DOI: 10.1021/OL501012F
关键词:
摘要: A method for efficient oxidative cleavage of vic-1,2-diols using a NaO(t)Bu-O2 system resulted in the formation carboxylic acids high yields. The present protocol is an eco-friendly alternative to conventional transition-metal-based method. This new strategy allows large-scale production with nonchromatographic purification while also suppressing competitive reaction pathway such as benzilic acid rearrangement.
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