Highly fluorescent carbon dots as an efficient nanoprobe for detection of clomifene citrate

摘要: Highly fluorescent carbon dots (CDs) were synthesized through facile hydrothermal carbonization and ethylenediamine passivation of an easily available prawn shell precursor. The as-prepared CDs exhibit high water solubility, wavelength-tunable fluorescence with quantum yield up to 68.9%, photostability resistance against biomolecules, thus enabling the application as viable nanoprobes for detection guest quenchers. can be effectively quenched by clomifene citrate (CC, a common drug infertility) static quenching, therefore serve simple efficient nanoprobe determination CC wide linear range (0.25–10 μg mL−1) low limit (0.2 mL−1). also showed cytotoxicity, which enables safe accurate spiked in human serum, demonstrating their potential credible clinical examination.