Transcriptional Networks of Embryonic Stem Cell-Derived Cardiomyogenesis

摘要: Embryonic stem cells are pluripotent that, if cultured under specific conditions, give rise to clusters of beating cardiomyocytes. Beating cardiomyocytes, also dubbed areas, display gene expression profiles and functional properties similar adult In line with this, a wide heterogeneity has been observed in embryonic cell-derived resembling thus the distinct characteristics atrial, ventricular conductive It recently demonstrated that two cardiogenic precursor contribute developing heart. The first heart field contributes cardiac linear straight tube while second population adds both arterial venous pole tube, delimiting field. As cardiogenesis advances mainly gives left ventricle, whereas right outflow tract atrial chambers. A third cells, fingerprint form inflow tract, suggesting possible existence Over last years we have gained insights about transcriptional mechanisms govern fields, however, our understanding such endogenous program is recapitulated cardiomyogenesis remains elusive. Within this review elaborate current state-of-the-art networks operate during cardiomyogenesis, special emphasis on development networks.