In Vitro Physico-Chemical Characterization and Standardized In Vivo Evaluation of Biocompatibility of a New Synthetic Membrane for Guided Bone Regeneration.

摘要: This study’s aim was to evaluate the biocompatibility and bioabsorption of a new membrane for guided bone regeneration (polylactic-co-glycolic acid associated with hydroxyapatite β-tricalcium phosphate) three thicknesses (200, 500, 700 µm) implanted in mice subcutaneously. Scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, quantification carbon, hydrogen nitrogen were used characterize physico-chemical properties. One hundred Balb-C divided into 5 experimental groups: Group 1—Sham (without implantation); 2—200 μm; 3—500 4—700 5—Pratix®. Each group subdivided four periods (7, 30, 60 90 days). Samples collected processed histological histomorphometrical evaluation. The membranes showed no moderate or severe tissue reactions during studied. 500-μm reaction any period. 200-μm began exhibit fragmentation after 30 days, while 700-µm at days. All studied biocompatible 500 µm best results absorption reaction, indicating its potential clinical regeneration.