Chemical and Biological Studies of cis — Diamminedichloroplatinum (II) Binding to DNA
作者： J. P. Caradonna , S. J. Lippard
DOI: 10.1007/978-1-4613-2837-7_3
关键词:
摘要: Over a decade has passed since the initial observation that neutral platinum amine coordination compounds with cis configuration of labile groups were effective chemotherapeutic agents.1 Subsequent studies built strong case DNA is relevant biological target these complexes.2,3 Substantial effort therefore been directed towards defining and characterizing interactions cis-Pt(NH3)2Cl2 (cis-DDP) inactive trans-Pt(NH3)2Cl2 (trans-DDP),4 structures which are shown in Figure 1, at molecular level.
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