Regulation of Somatomedin Production, Release, and Mechanism of Action

摘要: Early studies revealed that a pituitary factor, growth hormone (GH), was in-volved in long bone and nitrogen retention and, without conclusive evidence, accepted theories suggested GH interacted directly with target tissues to induce such adaptations metabolism. The elegant by Salmon Daughaday (1957) described factor normal serum that, when added cartilage expiants, stimulated the incorporation of 35S04 into proteoglycans. Serum from hypophysectomized rats failed stimulate sulfate incorporation; however, were treated GH, stimulation uptake observed within 24 hr. In contrast, direct addition expiant media, either -presence or absence rat serum, incorporation. Based on bioassay response, component named sulfation factor.