Computational and experimental assessment of influences of hemodynamic shear stress on carotid plaque.

摘要: Studies have identified hemodynamic shear stress as an important determinant of endothelial function and atherosclerosis. In this study, we assess the influences on carotid plaques. Carotid stenosis phantoms with three severity (30, 50, 70%) were made from 10% polyvinyl alcohol (PVA) cryogel. The placed in a pulsatile flow loop same systolic/diastolic phase (35/65) inlet rate (16 L/h). Ultrasonic particle imaging velocimetry (Echo PIV) computational fluid dynamics (CFD) used to calculate velocity profile distribution phantoms. Inlet/outlet boundary conditions CFD extracted Echo PIV experiments make sure that results comparable. showed was largest 70% than those 30 50% at peak systole. indicated larger upper wall surface plaque center vessel. demonstrated upstream downstream plaque. There no significant difference average obtained by 30% (p = 0.25). Velocities measured (93.01 cm/s) (115.07 cm/s) (60.26 ± 5.36 cm/s) (89.11 ± 7.21 cm/s). suggested could obtain Higher WSS occurred narrower arteries, shoulder bore higher bottom part.