DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients.

摘要: DJ-1 is a novel oncogene that can transform NIH3T3 cells in cooperation with the activated ras gene. appears to have its greatest effect on tumourigenesis, and it may greater impact early-stage lung cancers. In this study, we proposed investigate clinical value of protein early diagnosis cancer compared diagnostic other biomarkers. Preoperative serum levels were measured 300 patients benign pulmonary disease (n = 44) healthy volunteers 64). Using tissue microarrays immunohistochemical analyses, expression between primary squamous cell carcinoma tumours matched metastatic tissues from lymph node. The baseline preoperative was significantly higher than diseases controls (p < 0.001). subgroup, median concentration (ng/mL) advanced stage (12.90 vs 7.75, p 0.05). immunohistochemistry, observed staining intensity generally weaker less common tumour (McNemar-Bowker Test, 0.008). highly expressed cancer, decreased after metastasis. Therefore, be potential biomarker for monitoring