Shugoshin1 enhances multidrug resistance of gastric cancer cells by regulating MRP1, Bcl-2, and Bax genes
作者： Yafang Wang , Lili Liu , Xiangqiang Liu , Hui Zhang , Jiaming Liu
DOI: 10.1007/S13277-013-0758-3
关键词:
摘要: Multidrug resistance (MDR) is a major clinical obstacle in treatment of gastric cancer (GC) and it accounts for the majority cancer-related mortalities. Shugoshin1 (SGO1) an important player appropriate chromosome segregation involved tumorigenesis. In this study, we found endogenous SGO1 overexpression multidrug-resistant GC cell lines SGC7901/VCR SGC7901/ADR compared with their parental line SGC7901. By enhancing expression SGO1, sensitivity SGC7901 cells to vincristine (VCR), adriamycin, 5-fluorouracil (5-FU), cisplatin (CDDP) was significantly diminished. Silencing its resulted enhanced these antitumor drugs. Additionally, confirmed that increased capacity enable adriamycin (ADR) efflux inhibit drug-induced apoptosis by regulating MRP 1, Bcl-2, Bax genes so as confer MDR phenotype cells. brief, findings suggest promotes may be useful novel therapeutic target preventing or reversing MDR.
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