Protective role of TNF-α, IL-10 and IL-2 in mice infected with the Oshima strain of Tick-borne encephalitis virus
作者： Mya Myat Ngwe Tun , Kotaro Aoki , Masachika Senba , Corazon C. Buerano , Kenji Shirai
DOI: 10.1038/SREP05344
关键词:
摘要: Tick-borne encephalitis virus (TBEV) causes acute central nervous system disease. Here, we investigated the roles of TNF-α, IL-10 and other cytokines in appropriate KO mice following infection with Oshima Sofjin strains TBEV. Following strain, mortality rates were significantly increased TNF-α compared wild type (WT) mice. These results suggested that play protective against fatal due to strain infection. However, viral loads proinflammatory cytokine levels brain andIL-10 not different those WT On hand, all WT, died strain. Interestingly, Sofjin-infected did exhibit an up-regulated mRNA level IL-2 spleen groups mice, whereas Oshima-infected showed mock-infected From these results, suggest are key factors for disease remission from
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