Angiotensin II for the Treatment of Vasodilatory Shock

摘要: BackgroundVasodilatory shock that does not respond to high-dose vasopressors is associated with high mortality. We investigated the effectiveness of angiotensin II for treatment patients this condition. MethodsWe randomly assigned vasodilatory who were receiving more than 0.2 μg norepinephrine per kilogram body weight minute or equivalent dose another vasopressor receive infusions either placebo. The primary end point was a response respect mean arterial pressure at hour 3 after start infusion, defined as an increase from baseline least 10 mm Hg 75 Hg, without in background vasopressors. ResultsA total 344 one two regimens; 321 received study intervention (163 II, and 158 placebo) included analysis. reached by angiote...