Expression of the PAX2 gene in human fetal kidney and Wilms' tumor.

摘要: We have examined the pattern of expression human PAX2 gene in Wilms' tumors and fetal kidney by Northern blot situ hybridization. Human encodes a paired box-containing protein has high degree homology with mouse Drosophila box genes. In hybridization analysis reveals that is expressed nephrogenic structures also tumors. This suggests may role differentiation tissues kidney. kidney, rapidly attenuates following initial differentiation, but no evidence attenuation was found The timing restricted to development, although levels were observed rests residual normal juvenile tissue adjacent tumor. Nephrogenic are presumptive precursors tumor not necessarily neoplastic. failure attenuate be associated events leading onset By somatic cell hybrid mapping, localized chromosome 10q22.1-q24.3, this region previously been implicated