Effects of leptomycin b on the cell cycle of fibroblasts and fission yeast cells
作者： Minoru Yoshida , Mitsuo Nishikawa , Kazunori Nishi , Keiichi Abe , Sueharu Horinouchi
DOI: 10.1016/0014-4827(90)90129-X
关键词:
摘要: An antifungal antibiotic, leptomycin B (LMB), which induced cell elongation of fission yeast, Schizosaccharomyces pombe, was found to be a unique inhibitor the cycle mammalian and yeast cells. Proliferation rat 3Y1 fibroblasts reversibly blocked by LMB in both G1 G2 phases treated cells were presumably introduced into resting state (GO). After removal LMB, proliferative tetraploid produced from had been arrested at phase, as result DNA replication without passage through M phase. also inhibited proliferation S. pombe phases. These results suggest that molecular target is one components necessary for progression eukaryotic cycle.
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