F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check.
作者： Víctor M. Díaz , Antonio García de Herreros
DOI: 10.1016/J.SEMCANCER.2015.10.003
关键词:
摘要: F-box proteins are the key recognition subunit of multimeric E3 ubiquitin ligase complexes that participate in proteasome degradation specific substrates. In last years, a discrete number have been shown to regulate epithelial-to-mesenchymal transition (EMT), process defined by rapid change cell phenotype, loss epithelial characteristics and acquisition more invasive phenotype. Specific EMT transcription factors (EMT-TFs), such as Snail, Slug, Twist Zeb, control induction both during development cancer. These EMT-TFs short-lived targeted system proteins, keeping them at low levels. also indirectly controlling inducers, Notch, c-Myc or mTOR. Here we summarize role these (Fbxw1, Fbxw7, Fbxl14, Fbxl5, Fbxo11 Fbxo45) play cancer progression, dependent on post-translational modifications govern their interaction with target proteins.
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