Immunotoxins, Resistance and Cancer Stem Cells: Future Perspective

摘要: Cancer relapse or recurrence has been the greatest challenge in treatment of this life threatening disease, which occurs due to resistance cancer cells drug radiation therapy. Most often is developed during treatment, makes it even more complicated, leading failure chemo therapy majority cases. To circumvent these problems associated with conventional therapies, newer strategies were adopted like targeted using monoclonal antibodies, immunotoxins and antibody-drug conjugates. However, also showed many vitro vivo studies that was again attributed emergence resistant cells. Here, we discuss various factors cellular mechanisms responsible for against therapies approaches recombinant immunotoxins. stem (CSC’s) identified as major reason their role proved convincingly recent studies. Hence, involved CSC’s have elaborated. We summarize being currently overcome different means targeting could be used future.