Prediction of Response to Targeted Treatment in Rheumatoid Arthritis

摘要: Rheumatoid arthritis is an autoimmune syndrome presenting with chronic inflammation of the joints. Patients same diagnosis can present different phenotypes. In some patients severe joint and early destruction are observed, whereas a milder phenotype be seen in others. Conversely, signs symptoms may exhibit immunological molecular abnormalities. Since introduction treatment clinical practice, treat to target principle, new medicines such as biologic disease-modifying antirheumatic drugs, remission achieved disease course, albeit not all patients. The response efficacy drugs vary among individuals. Therefore, there need develop more personalized approach toward achieve rapid every patient prevent disability restore maintain quality life, without unnecessary adverse effects, cost-effective manner. latest data from explorative studies predictive markers discussed here, together preliminary algorithm based on currently available knowledge.