Indispensable role of the voltage-gated calcium channels in the procognitive effects of angiotensin IV.

摘要: Abstract Background Voltage-gated calcium channels (VGCCs) play a major role in brain functioning, including that of cognition-related structures such as cerebral cortex and hippocampus. Cellular mechanisms underlying learning memory enhancing effect the neuropeptide angiotensin IV (Ang IV) have been linked to VGCCs but only respect its long-term potentiation (LTP)-inducing effect. Objective To assess behaviorally effects L- T-type blocking drugs low, inactive, doses on Ang facilitation recall aversively (foot-shock) appetitively (curiosity for novelty) motivated behaviors. Methods About 240 male Wistar rats were used. All animals received oral (p.o.) dose nimodipine (12 mg/kg) or mibefradil (1 mg/kg) dissolved saline alone followed by an intracerebroventricular (i.c.v.) injection 1 nmol 2 μl normal 15 min later. Groups about 10 rats, separate each experiment, tested (inhibitory avoidance, IA) (object recognition, OR) reinforced verify lack unspecific motor emotional our treatments groups open field (OF) elevated ‘plus’ maze (EPM), respectively. Results Both, prevented facilitating subsequently injected IV. The peptide well both had no (OF), negligible (EPM) performance emotionality rats. Conclusion data support notion key functional neuronal procognitive