A randomized study of radiotherapy versus radiotherapy plus chemotherapy in stage I-II non-hodgkin's lymphomas
作者： Nis I. Nissen , Jens Ersbøll , Hanne Sand Hansen , Sven Walbom-Jørgensen , Jens Pedersen-Bjergaard
DOI: 10.1002/1097-0142(19830701)52:1<1::AID-CNCR2820520102>3.0.CO;2-M
关键词:
摘要: In a randomized, prospective trial from 1974-1978, 73 patients with non-Hodgkin's lymphomas in clinical Stage I or II were treated extended field radiotherapy alone (RT) RT plus adjuvant chemotherapy vincristine, streptonigrin, cyclophosphamide and prednisone (RT + CT). With median follow-up time of five years, 54% have relapsed the group versus only 10% CT (P less than 0.01). There is no statistical difference overall survival yet, but 13/14 deaths 3/12 due to progressive disease. Among unfavorable histology, 13/22 died disease progression against 3/34 The results are agreement those two other series published detail. Based on these we therefore recommend use all I-II histology. Further observation necessary before conclusion can be drawn for lymphoma more favorable
sci-hub.se 参考文章(12)
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Henry S. Kaplan, Clinical Evaluation and Radiotherapeutic Management of Hodgkin's Disease and the Malignant Lymphomas New England Journal of Medicine. ,vol. 278, pp. 892- 899 ,(1968) , 10.1056/NEJM196804182781606
Torsten G. Landberg, Leif G. Håkansson, Torgil R. Möller, Willy K. I. Mattsson, Karol E. Landys, Bo G. Johansson, Dick C. F. Killander, Bjö Rn F. Molin, Per F. Westling, Per H. Lenner, Olov G. Dahl, CVP—Remission—maintenance in stage I or II non-Hodgkin's lymphomasPreliminary results of a randomized study Cancer. ,vol. 44, pp. 831- 838 ,(1979) , 10.1002/1097-0142(197909)44:3<831::AID-CNCR2820440307>3.0.CO;2-S
ThomasP. Miller, StephenE. Jones, CHEMOTHERAPY OF LOCALISED HISTIOCYTIC LYMPHOMA The Lancet. ,vol. 313, pp. 358- 360 ,(1979) , 10.1016/S0140-6736(79)92894-0
Stephen E. Jones, Zvi Fuks, Henry S. Kaplan, Saul A. Rosenberg, Non-Hodgkin's lymphomas.V. Results of radiotherapy Cancer. ,vol. 32, pp. 682- 691 ,(1973) , 10.1002/1097-0142(197309)32:3<682::AID-CNCR2820320322>3.0.CO;2-M
Don R. Goffinet, Ronald A. Castellino, Hun Kim, Ronald F. Dorfman, Zvi Fuks, Saul A. Rosenberg, Thomas Nelsen, Henry S. Kaplan, Staging laparotomies in unselected previously untreated patients with non-Hodgkin's lymphomas Cancer. ,vol. 32, pp. 672- 681 ,(1973) , 10.1002/1097-0142(197309)32:3<672::AID-CNCR2820320321>3.0.CO;2-Q
Henry Rappaport, William J. Winter, Ethel B. Hicks, Follicular lymphoma.A re-evaluation of its position in the scheme of malignant lymphoma based on a survey of 253 cases Cancer. ,vol. 9, pp. 792- 821 ,(1956) , 10.1002/1097-0142(195607/08)9:4<792::AID-CNCR2820090429>3.0.CO;2-B
E. A. Gehan, A generalized Wilcoxon test for comparing arbitrarily singly-censored samples Biometrika. ,vol. 52, pp. 203- 223 ,(1965) , 10.1093/BIOMET/52.1-2.203
Nis I. Nissen, Chemotherapy With or Without Radiotherapy in Malignant Lymphomas1,2 Application of Cancer Chemotherapy. ,vol. 24, pp. 73- 82 ,(1978) , 10.1159/000401502
Roy Goulding, G.N. Volans, Peter Crome, Brian Widdop, Roger Williams, Letter: Paracetamol hepatoxicity. The Lancet. ,vol. 1, pp. 358- ,(1976) , 10.1016/S0140-6736(76)90106-9