Efeitos comportamentais e bioquímicos da dieta intermitente na vigência de um estímulo inflamatório no hipocampo de ratos.

摘要: Vasconcelos AR. Behavioral and biochemical effects of intermittent fasting in the presence or absence an inflammatory stimulus (LPS) rat hippocampus [Master Pharmacology]. Sao Paulo: Instituto de Ciencias Biomedicas da Universidade Paulo; 2011. Hormesis is adaptive response cells organisms to a moderate stress, usually intermittent, which may have many beneficial biological system. Examples include exposure low doses certain phytochemicals such as curcumin, resveratrol isothiocyanates, exercise dietary restriction. The latter, when it does not cause malnutrition, induces nutritional stress organism, only stimulates proteins, but also body's defense mechanisms, making cell organism more resistant toxic stimuli. In general, seems act by mechanisms associated with survival response, thereby involving nuclear transcription factor kappa B (NF-κB) modulation. However, little known about molecular involved, well involvement hormesis signaling pathways important neurogenesis neuroprotection, cyclic AMP element (CREB) WNT, its correlation signaling. present work investigates on memory learning, WNT CREB NF-κB factors gene expression regulated these stimulus, represented intravenous administration lipopolysaccharide (LPS). results showed that improved performance Barnes maze inhibitory avoidance behavioral tests even treated LPS. Also, induced both increase phosphorylated canonical pathway, changes mRNA markers levels, as, decreasing toll-like receptor-4 (Tlr-4), nitric oxide synthase (iNos) cyclooxygenase 2 (Cox-2). addition, can interleukin (IL)-10/tumor necrosis (TNF) ratio levels compared control group. Taken together, our suggest restriction prevalence protective cascades central nervous system (CNS).