Obesity and Joint Disease

摘要: Obesity is a risk factor for joint disease, in particular osteoarthritis, at both weight-bearing joints such as the knee, and non-weight bearing carpometacarpal of hand. Despite this, how obesity mechanistically associated with disease unclear. Both metabolic biomechanical factors are likely to mediate association between although different tissues bone cartilage differ their response adiposity. It may be that contribute more whereas predispose changes relatively joints, those This chapter aims examine evidence role pathology using osteoarthritis paradigm.