Therapeutic Protective Effects of IL-12 Combined with Soluble IL-4 Receptor Against Established Infections of Herpes Simplex Virus Type 1 in Thermally Injured Mice
作者： David N. Herndon , Richard B. Pollard , Makiko Kobayashi , Fujio Suzuki , Tokuichiro Utsunomiya
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摘要: The effect of combination therapy between IL-12 and soluble IL-4R (sIL-4R) on the established infection HSV-1 in thermally injured mice (TI mice) was investigated. All TI infected with lethal amounts died when given therapeutically at a dose 500 U/mouse. However, 80% these treated prophylactically survived compared 0% survival same saline. therapeutic administration to currently caused an treatment combined sIL-4R. Although did not stimulate IFN-γ production cultures splenic T cells from mice, produced by stimulation producer were prepared that had been previously After anti-CD3 mAb, IL-4 into their culture fluids. sIL-4R combination. results obtained herein indicate efficacies against may result stimulated are for reducing burn-associated type 2 cell responses.
elsevier.com参考文章(46)
F P Heinzel, D S Schoenhaut, R M Rerko, L E Rosser, M K Gately, Recombinant interleukin 12 cures mice infected with Leishmania major. Journal of Experimental Medicine. ,vol. 177, pp. 1505- 1509 ,(1993) , 10.1084/JEM.177.5.1505
Dorothee Decker, Martin Schöndorf, Frank Bidlingmaier, Andreas Hirner, Alexander A. von Ruecker, Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma Surgery. ,vol. 119, pp. 316- 325 ,(1996) , 10.1016/S0039-6060(96)80118-8
Phillip Scott, Stefan H.E. Kaufmann, The role of T-cell subsets and cytokines in the regulation of infection Immunology Today. ,vol. 12, pp. 346- 348 ,(1991) , 10.1016/0167-5699(91)90063-Y
Susanne J. Szabo, Nile G. Jacobson, Anand S. Dighe, Uell Gubler, Kenneth M. Murphy, Developmental commitment to the Th2 lineage by extinction of IL-12 signaling Immunity. ,vol. 2, pp. 665- 675 ,(1995) , 10.1016/1074-7613(95)90011-X
P. Puccetti, A. Mencacci, E. Cenci, R. Spaccapelo, P. Mosci, K.-H. Enssle, L. Romani, F. Bistoni, Cure of Murine Candidiasis by Recombinant Soluble Interleukin-4 Receptor The Journal of Infectious Diseases. ,vol. 169, pp. 1325- 1331 ,(1994) , 10.1093/INFDIS/169.6.1325
Eugen Faist, Depression of Cellular Immunity After Major Injury Archives of Surgery. ,vol. 121, pp. 1000- 1005 ,(1986) , 10.1001/ARCHSURG.1986.01400090026004
RICHARD J. KAGAN, SIRUS NARAQI, TAKAYOSHI MATSUDA, OLGA M. JONASSON, Herpes simplex virus and cytomegalovirus infections in burned patients. Journal of Trauma-injury Infection and Critical Care. ,vol. 25, pp. 40- 45 ,(1985) , 10.1097/00005373-198501000-00007
Sergo Romagnani, Understanding the role of Th1/Th2 cells in infection Trends in Microbiology. ,vol. 4, pp. 470- 473 ,(1996) , 10.1016/S0966-842X(97)82906-X
Thuan T. Nguyen, David A. Gilpin, Nicholas A. Meyer, David N. Herndon, Current treatment of severely burned patients. Annals of Surgery. ,vol. 223, pp. 14- 25 ,(1996) , 10.1097/00000658-199601000-00004
K Kawakami, M Tohyama, X Qifeng, A Saito, Expression of cytokines and inducible nitric oxide synthase mRNA in the lungs of mice infected with Cryptococcus neoformans: effects of interleukin-12. Infection and Immunity. ,vol. 65, pp. 1307- 1312 ,(1997) , 10.1128/IAI.65.4.1307-1312.1997