Mycophenolic acid exposure and complement fraction C3 influence inosine 5′-monophosphate dehydrogenase activity in systemic lupus erythematosus:
作者： Yasuaki Mino , Takafumi Naito , Kumiko Shimoyama , Noriyoshi Ogawa , Junichi Kawakami
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摘要: BackgroundMycophenolate mofetil has recently been reported to be effective against systemic lupus erythematosus. The influence of the pharmacokinetics mycophenolic acid, active form mycophenolate and major inactive acid phenolic glucuronide on activity target enzyme inosine 5′-monophosphate dehydrogenase, is expected revealed. aim this study was identify factors associated with dehydrogenase in erythematosus patients.MethodsFifty patients remission maintenance phase (29 received [MMF+] 21 did not [MMF−]) were enrolled. Median interquartile range dose 1500 1000–1500 mg/day, respectively. Stepwise multiple linear regression analysis performed assess dependence between 25 predictor values including predose plasma concentrations free ...
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