Clinicopathological studies on canine dirofilarial hemoglobinuria.

摘要: Pathological and etiological features were examined clinicopathologically in cases of canine dirofilarial hemoglobinuria. Dogs suffering from serious filariasis without hemoglobinuria, as well normal healthy dogs, used controls. This disease is frequent male dogs 3 years or more age. Its incidence high February, March April. Direct Coombs' test was negative 5 Groups hemoglobinuria showed an increase osmotic mechanical fragility erythrocytes, characteristic poikilocytes, mean corpuscular constants, suggesting hemolytic anemia, liver dysfunction, free cholesterol level serum, decrease lecithin acyltransferase activity, hemosiderinuria. The latency chronic intravascular hemolysis also confirmed the group filariasis. differed significantly this group. It filarial embolism venae cavae, marked acute blood glucose BUN levels, α/total -β ratio serum lipoproteins. In discussing development pathological attention paid to severe disturbances subsequent congestion caused by cavae with worms. increased content lipoproteins presumed be extracorpuscular factor, accompanying exchange erythrocyte membrane possible destruction erythrocytes a physical collision worms suggested rather direct causes hemolysis.