Prevalence and risks of hepatitis E virus infection in blood donors from the Western Cape, South Africa.

摘要: Background Transfusion-transmitted hepatitis E virus (HEV) infection is a potential risk to recipients of blood transfusions. Infection with HEV poses high immunocompromised an increased likelihood developing chronic infection. The aims this study were determine the prevalence past and active infections in donors from Western Cape identify factors associated Materials methods We prospectively tested 10 250 for A factor sub-study investigated who completed questionnaire, plasma samples IgG antibodies pooled RNA detection. demographic assessed. molecular 000 individual donations using commercial assay detect viraemia. viral load genotype also determined. Results overall anti-HEV seroprevalence was 42·8% (107/250) among participating sub-study. higher increase age. Of donor individually RNA, one sample positive 7·9 x 104 IU/ml belonged 3. Conclusion found but low Cape, South Africa. provides evidence contamination supply cost-benefit analysis needed before considering introduction routine screening our setting.