Development of a water-in-oil-in-water multiple emulsion system integrating biomimetic aqueous-core lipid nanodroplets for protein entity stabilization. Part II: process and product characterization

作者: Cássia A. Glasser , Marta M. D. C. Vila , Júlio C. Pereira , Marco V. Chaud , José M. Oliveira Júnior

DOI: 10.1080/03639045.2016.1188109

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摘要: AbstractThe aqueous-core enclosed in lipid nanoballoons integrating multiple emulsions of the type water-in-oil-in-water mimic, at least theory, environment within viable cells, thus being suitable for housing hydrophilic protein entities such as bioactive proteins, peptides and bacteriophage particles. This study reports a complete physicochemical characterization optimized biomimetic (BSA) entities, evolved from statistical 23×31 factorial design (three variables two levels one variable three levels) that was subject first paper series three, aiming stabilization three-dimensional structure attempted via said molecular (W/O/W) emulsion. The followed led to production an optimum W/O/W emulsion possessing quite homogeneous pa...

参考文章(27)
Victor M. Balcão, Sérgio V. P. Barreira, Thiago M. Nunes, Marco V. Chaud, Matthieu Tubino, Marta M. D. C. Vila, Carbohydrate Hydrogels with Stabilized Phage Particles for Bacterial Biosensing: Bacterium Diffusion Studies Applied Biochemistry and Biotechnology. ,vol. 172, pp. 1194- 1214 ,(2014) , 10.1007/S12010-013-0579-2
Timothy A. Nieman, Douglas A. Skoog, F. James Holler, Principles of Instrumental Analysis ,(1971)
Marina Gallarate, Michele Trotta, Luigi Battaglia, Daniela Chirio, Preparation of solid lipid nanoparticles from W/O/W emulsions: preliminary studies on insulin encapsulation. Journal of Microencapsulation. ,vol. 26, pp. 394- 402 ,(2009) , 10.1080/02652040802390156
Joana Araújo, Elisabet Gonzalez, Maria Antonia Egea, Marisa Luisa Garcia, Eliana B Souto, None, Nanomedicines for ocular NSAIDs: safety on drug delivery Nanomedicine: Nanotechnology, Biology and Medicine. ,vol. 5, pp. 394- 401 ,(2009) , 10.1016/J.NANO.2009.02.003
J Araújo, E Vega, C Lopes, MA Egea, ML Garcia, EB Souto, None, Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres Colloids and Surfaces B: Biointerfaces. ,vol. 72, pp. 48- 56 ,(2009) , 10.1016/J.COLSURFB.2009.03.028
Manju RAWAT, Deependra SINGH, S. SARAF, Swarnlata SARAF, Lipid carriers: a versatile delivery vehicle for proteins and peptides. Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan. ,vol. 128, pp. 269- 280 ,(2008) , 10.1248/YAKUSHI.128.269
Kenji Katayama, Hiroko Nomura, Hiroki Ogata, Takeshi Eitoku, Diffusion coefficients for nanoparticles under flow and stop-flow conditions Physical Chemistry Chemical Physics. ,vol. 11, pp. 10494- 10499 ,(2009) , 10.1039/B911535H
Sixing Yang, Weien Yuan, Tuo Jin, Formulating protein therapeutics into particulate forms. Expert Opinion on Drug Delivery. ,vol. 6, pp. 1123- 1133 ,(2009) , 10.1517/17425240903156374
M. Reza Mozafari, Kianoush Khosravi-Darani, G. Gokce Borazan, Jian Cui, Abbas Pardakhty, Seyhun Yurdugul, Encapsulation of Food Ingredients Using Nanoliposome Technology International Journal of Food Properties. ,vol. 11, pp. 833- 844 ,(2008) , 10.1080/10942910701648115
Victor M. Balcão, Marta M.D.C. Vila, Structural and functional stabilization of protein entities: state-of-the-art. Advanced Drug Delivery Reviews. ,vol. 93, pp. 25- 41 ,(2015) , 10.1016/J.ADDR.2014.10.005