Concomitant Duplication Of The Cid And Cenp-C Genes In Drosophila

摘要: The constitutive centromeric proteins CenH3 and Cenp-C are interdependent in their role of establishing centromere identity function. In a recent paper, Kursel Malik (February 2017; doi: 10.1093/molbev/msx091) reported that the Drosophila homologue Cid underwent four independent duplication events during evolution. Particularly interesting is took place common ancestor subgenus led to subfunctionalization high divergence Cid1 Cid5 paralogs. Here, we describe another (Cid1 leading Cid6) buzzatii cluster (repleta group) subgenus. Moreover, found that, addition Cid1/Cid5 duplication, was also duplicated (Cenp-C1, Cenp-C2) Analyses expression tests for positive selection indicate both Cenp-C2 male germline-biased evolved adaptively, indicating Our findings further highlight strong interdependence between Cenp-C, paving way new perspectives by which function evolution can be addressed.