Exposure to di(2-ethylhexyl) phthalate in premature neonates in a neonatal intensive care unit in Taiwan.

摘要: OBJECTIVE Neonates are exposed to high levels of di(2ethylhexyl) phthalate through numerous medical procedures in the neonatal intensive care unit. Our aim was assess contribution specific devices di(2-ethylhexyl) exposure neonates. DESIGN Prospective. SETTING University hospital. PATIENTS We recruited 32 premature neonates, 20 with very low birth weight (<1500 g) and 12 (<2500 g), 31 controls at a unit from center central Taiwan. INTERVENTIONS Interventions were based on clinical need used standard materials devices, including endotracheal tubes, continuous positive airway pressure, oxygen hood, intravenous injection, intralipid blood transfusion, orogastric nasogastric umbilical venous catheterization, arterial chest tube, isolate. MEASUREMENTS AND MAIN RESULTS recorded each subject, collected their urine samples, determined urinary concentration three metabolites using reversed-phase high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. Median neonates treated an tube or significantly higher than those not tube. injection ≥ 2-fold healthy who received injections (p = .01). similar very-low-birth-weight low-birth-weight CONCLUSIONS These data suggest that polyvinyl chloride-containing major defining factor urge use chloride-free alternative especially for tubing The health effects is worthy further investigation.