Common low complexity regions for SARS-CoV-2 and human proteomes as potential multidirectional risk factor in vaccine development

摘要: Abstract The rapid spread of the COVID-19 demands immediate response from scientific communities. Appropriate countermeasures mean thoughtful and educated choice viral targets (epitopes). There are several articles that discuss such choices in SARS-CoV-2 proteome, other focus on phylogenetic traits history Coronaviridae genome/proteome. However none consider protein low complexity regions (LCRs). Recently we created first methods able to compare fragments. We show five (LCRs) three proteins (nsp3, S N) encoded by genome highly similar human proteome. As many as 21 predicted T-cell epitopes 27 B-cell overlap with LCRs proteins. Interestingly, replication central part RNA devoid LCRs. Similarity may have implications ability virus counteract immune defenses. vaccine targeted potentially be ineffective or alternatively lead autoimmune diseases development. These findings crucial process selection new for drugs vaccines which should omit regions. Author summary outbreak disease affects humans all over globe. More more people get sick die because deadly virus. whole machinery this pathogen is enclosed a short sequence nucleotides, building blocks both DNA strands. This encodes less than 30 sequences change fate our societies. Its composed 20 amino acids (building bricks) usually used quite freely However, there fragments where only one few used. name those invented programmes Using methodology were similarity some ones. discovery has serious implication when designing drugs. It means companies not use these very it trigger an disease. On hand specific suggest kind disguise into cells.