Pathways of myocyte death: implications for development of clinical laboratory biomarkers.

摘要: The recognition that cardiac myocytes die by multiple mechanisms and thus substantially affect ventricular remodeling in diseased human hearts supports the concept of ongoing myocyte death progression heart failure constitutes basis this review. In addition, based on pathophysiology myocardial cell deaths, present study emphasizes currently methodologies, although with some inherent limitations, are available to recognize measure quantitatively contribution pathologic state heart. Our own studies show application such methodologies including modern microscopy techniques use different molecular immunohistochemical markers may generate consensus is a quantifiable parameter normal pathological also demonstrates death, apoptotic, oncotic or autophagic nature, has be regarded as an additional critical variable multifactorial events implicated alterations anatomy structure