Genotyping of Plasmodium vivax reveals both short and long latency relapse patterns in Kolkata.

摘要: Background The Plasmodium vivax that was once prevalent in temperate climatic zones typically had an interval between primary infection and first relapse of 7–10 months, whereas tropical areas P.vivax infections frequently at intervals 3–6 weeks. Defining the epidemiology these two phenotypes from temporal patterns illness endemic is difficult or impossible, particularly if they overlap. Methods A prospective open label comparison chloroquine (CQ) alone versus CQ plus unobserved primaquine for either 5 days 14 conducted patients presenting with acute malaria Kolkata. Patients were followed 15 months recurrent genotyped using three polymorphic antigen up to 8 microsatellite markers. Results 151 enrolled whom 47 (31%) subsequent infections. Recurrence proportions similar treatment groups. Parasite genotyping revealed discrete recurrence allowing differentiation probable newly acquired This suggested 32 recurrences relapses which 22 (69%) genetically homologous. majority (81%) occurred within (16 homologous, 10 heterologous) six homologous (19%) long latency (8–10 month interval) phenotype. Conclusions With follow-up assess recurrence, can be used rates. day course did not prevent relapse. Genotyping indicates West Bengal, after latent periods are Trial Registration Controlled-Trials.com ISRCTN14027467