Reply: Relevance of the PP2A Pathway in the Molecular Mechanisms of Chronic Obstructive Pulmonary Disease.

M. Kathryn Steiner, Olga L. Syrkina, Narasaish Kolliputi, Eugene J. Mark, Charles A. Hales, Aaron B. Waxman, Interleukin-6 Overexpression Induces Pulmonary Hypertension Circulation Research. ,vol. 104, pp. 236- 244 ,(2009) , 10.1161/CIRCRESAHA.108.182014

Sokratis A Apostolidis, Noé Rodríguez-Rodríguez, Abel Suárez-Fueyo, Nikolina Dioufa, Esra Ozcan, José C Crispín, Maria G Tsokos, George C Tsokos, Phosphatase PP2A is requisite for the function of regulatory T cells Nature Immunology. ,vol. 17, pp. 556- 564 ,(2016) , 10.1038/NI.3390

Christophe Côme, Anna Cvrljevic, Mohd Moin Khan, Irina Treise, Thure Adler, Juan Antonio Aguilar-Pimentel, Byron Au-Yeung, Eleonora Sittig, Teemu Daniel Laajala, Yiling Chen, Sebastian Oeder, Julia Calzada-Wack, Marion Horsch, Tero Aittokallio, Dirk H. Busch, Markus W. Ollert, Frauke Neff, Johannes Beckers, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Zhi Chen, Riitta Lahesmaa, Jukka Westermarck, CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection PLOS ONE. ,vol. 11, pp. e0152996- ,(2016) , 10.1371/JOURNAL.PONE.0152996

Walker M. McHugh, William W. Russell, Andrew J. Fleszar, Paul E. Rodenhouse, Skyler P. Rietberg, Lei Sun, Thomas P. Shanley, Timothy T. Cornell, Protein phosphatase 2A activation attenuates inflammation in murine models of acute lung injury. American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 311, ,(2016) , 10.1152/AJPLUNG.00007.2016

Jaya Sangodkar, Abbey Perl, Rita Tohme, Janna Kiselar, David B. Kastrinsky, Nilesh Zaware, Sudeh Izadmehr, Sahar Mazhar, Danica D. Wiredja, Caitlin M. O’Connor, Divya Hoon, Neil S. Dhawan, Daniela Schlatzer, Shen Yao, Daniel Leonard, Alain C. Borczuk, Giridharan Gokulrangan, Lifu Wang, Elena Svenson, Caroline C. Farrington, Eric Yuan, Rita A. Avelar, Agnes Stachnik, Blake Smith, Vickram Gidwani, Heather M. Giannini, Daniel McQuaid, Kimberly McClinch, Zhizhi Wang, Alice C. Levine, Rosalie C. Sears, Edward Y. Chen, Qiaonan Duan, Manish Datt, Shozeb Haider, Avi Ma’ayan, Analisa DiFeo, Neelesh Sharma, Matthew D. Galsky, David L. Brautigan, Yiannis A. Ioannou, Wenqing Xu, Mark R. Chance, Michael Ohlmeyer, Goutham Narla, Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth Journal of Clinical Investigation. ,vol. 127, pp. 2081- 2090 ,(2017) , 10.1172/JCI89548

Satoru Yanagisawa, Jonathan R. Baker, Chaitanya Vuppusetty, Peter Fenwick, Louise E. Donnelly, Kazuhiro Ito, Peter J. Barnes, Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 313, ,(2017) , 10.1152/AJPLUNG.00382.2016

Sridesh Nath, Michael Ohlmeyer, Matthias A. Salathe, Justin Poon, Nathalie Baumlin, Robert F. Foronjy, Patrick Geraghty, Chronic Cigarette Smoke Exposure Subdues PP2A Activity by Enhancing Expression of the Oncogene CIP2A American Journal of Respiratory Cell and Molecular Biology. ,vol. 59, pp. 695- 705 ,(2018) , 10.1165/RCMB.2018-0173OC

Xiuying Li, Toru Nyunoya, PP2A as a New Player in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology. ,vol. 59, pp. 659- 660 ,(2018) , 10.1165/RCMB.2018-0242ED

Declan F. Doherty, Sridesh Nath, Justin Poon, Robert F. Foronjy, Michael Ohlmeyer, Abdoulaye J. Dabo, Matthias Salathe, Mark Birrell, Maria Belvisi, Nathalie Baumlin, Michael D. Kim, Sinéad Weldon, Clifford Taggart, Patrick Geraghty, Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function American Journal of Respiratory and Critical Care Medicine. ,vol. 200, pp. 51- 62 ,(2019) , 10.1164/RCCM.201808-1518OC

Adam M Collison, Junyao Li, Ana Pereira De Siqueira, Xuejiao Lv, Hamish D Toop, Jonathan C Morris, Malcolm R Starkey, Philip M Hansbro, Jie Zhang, Joerg Mattes, None, TRAIL signals through the ubiquitin ligase MID1 to promote pulmonary fibrosis. BMC Pulmonary Medicine. ,vol. 19, pp. 31- ,(2019) , 10.1186/S12890-019-0786-X