Upregulation of hsa-miR-196a-5p is associated with MIR196A2 methylation and affects the malignant biological behaviors of glioma

摘要: Abstract Hsa-miR-196a-5p is involved in tumorigenesis and progression. However, the driving factors for hsa-miR-196a-5p overexpression its correlation with clinicopathological features prognosis of patients remain unclear glioma. Thus, this study aimed to investigate prognostic value MIR196A2 methylation We observed that expression was upregulated Next, 112 were divided into high (n = 56) low groups. The chi-square test showed significantly related age, WHO grade, histopathology, IDH mutation status, 1p/19q codeletion. Univariate multivariate Cox regression analyses an independent factor. GO KEGG enrichment may be MAPK signaling, focal adhesion cancer-related pathways. Compared normal astrocyte cell line, glioma lines had unregulated level, which confirmed by TCGA data. hypermethylated CpG sites mainly concentrated gene body region, associated overexpression. Kaplan-Meier curves revealed hypermethylation a poor These findings suggest malignant biological behaviors, overexpression, factor Therefore, act as early marker