Childhood acute lymphoblastic leukaemia and indicators of early immune stimulation: the Estelle study (SFCE)

摘要: Background: Factors related to early stimulation of the immune system (breastfeeding, proxies for exposure infectious agents, normal delivery, and animals in life) have been suggested decrease risk childhood acute lymphoblastic leukaemia (ALL). Methods: The national registry-based case-control study, ESTELLE, was carried out France 2010-2011. Population controls were frequency matched with cases on age gender. participation rates 93% 86% controls. Data obtained from structured telephone questionnaires administered mothers. Odds ratios (OR) estimated using unconditional regression models adjusted age, gender, potential confounders. Results: In all, 617 ALL 1225 aged >= 1 year included. Inverse associations between common infections (OR = 0.8, 95% confidence interval (CI): 0.6, 1.0), non-first born (>= 3 vs 1; OR 0.7, CI: 0.5, attendance a day-care centre before breastfeeding regular contact pets 1.0) infancy observed. Conclusions: results support hypothesis that conditions promoting maturation protective role respect ALL.