Acyl-CoA:Cholesterol Acyltransferase Inhibition Reduces Atherosclerosis in Apolipoprotein E–Deficient Mice
作者： Jun Kusunoki , Dipal K. Hansoty , Katsumi Aragane , John T. Fallon , Juan J. Badimon
DOI: 10.1161/01.CIR.103.21.2604
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摘要: Background—Acyl-CoA: cholesterol acyltransferase (ACAT) converts cholesterol to cholesteryl esters. The form of ACAT in macrophages, ACAT1, contributes to foam cell formation in the arterial wall and the development of atherosclerosis. Recent studies in a mouse model of atherosclerosis (the apolipoprotein E [apoE]–deficient mouse), however, have suggested that complete deficiency of ACAT1 activity is not antiatherogenic, in part because of toxicity resulting from adverse effects on tissue cholesterol homeostasis. We …
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