Age at epilepsy onset in patients with focal cortical dysplasias, gangliogliomas and dysembryoplastic neuroepithelial tumours.
作者： Attila Rácz , Andreas-Markus Müller , Johannes Schwerdt , Albert Becker , Hartmut Vatter
DOI: 10.1016/J.SEIZURE.2018.04.002
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摘要: Abstract Purpose The age at epilepsy onset in patients with inborn or very early acquired brain lesions depends on the epileptogenic potential of lesion and patients' individual "susceptibility" to epileptic seizures. To gain insight into these determinants, we analysed case history focal cortical dysplasias (FCDs) neuroglial tumours. Methods In a systematic, retrospective analysis comprised 233 who underwent surgery (116 FCDs 117 tumours), evaluated according histopathologic subgroups, location family history. Results Epilepsy was significantly earlier FCD than for those tumours (FCDs: 8.06 ± 0.74 years, gangliogliomas: 15.86 ± 1.24 years, dysembryoplastic neuroepithelial (DNTs): 19.18 ± 2.47 years; p Conclusion We postulate that difference between can be attributed – least partially unidentified genetic factors underlying tissue. Additionally, large variance is possibly also genetically determined.
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