Cyclodextrin Complex Osmotic Tablet for Glipizide Delivery
作者： Yong Gan , Weisan Pan , Mingchun Wei , Ruhua Zhang
关键词:
摘要: ABSTRACTPoorly soluble glipizide was selected as the model drug to prepare osmotic pump tablets (OPT) with proper accessorial material after it made an inclusion complex by kneading method in order increase solubility. Polyethylene glycol 4000 (PEG4000) and cellulose acetate (CA) were coating materials, acetone–water (95:5) co-solvent employed medium. The effects of promoting agent, diameter drug-releasing orifice, composition, coat weight on release profile investigated. optimal formulation compared a commercialized push–pull tablet. results indicated that glipizide–cyclodextrin OPT had excellent zero-order characteristics vitro.
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