Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport.

摘要: Nuclear transport receptors of the karyopherin superfamily proteins macromolecules from one compartment to other and are critical for both cell physiology pathophysiology. The nuclear machinery is tightly regulated essential a number key cellular processes since spatiotemporally expression many transporters themselves crucial activities. Dysregulation results in localization shifts specific cargo associates with pathogenesis disease states such as cancer, inflammation, viral illness neurodegenerative diseases. Therefore, inhibition system has future potential therapeutic intervention could contribute elucidation mechanisms. In this review, we recapitulate clue findings pathophysiological significance describe development inhibitors. Finally, clinical implications first trials discussed most promising