The influence of acute hypothermia on renal function of anaesthetized euthermic and acclimatized rats

摘要: Acute hypothermia has a major impact on cardiovascular control and renal function, but the extent to which these can be correlated with influenced by changes in altered pattern of sympathetic outflow kidneys is unclear. Moreover, it unknown whether responses acute are chronic cold exposure this study aimed examine factors. Renal function nerve activity (RSNA) were measured male Wistar rats, euthermic (control) or acclimatized (exposed progressively lower environmental temperature photoperiod over 8 weeks), anaesthetized chloralose/urethane. Reduction core (Tc) 25 degrees C caused approximately 40% reduction heart rate (HR), 10% fall mean arterial blood pressure (MABP), decreased glomerular filtration (GFR) 50% 5% respectively. At C, urine flow increased some two-fold absolute fractional sodium excretions 4- 6-fold rats lesser while basal levels fluid excretion higher rats. A loss pulsatility RSNA signal cooling was seen both groups. One factors contributing modest hypotension during RSNA. There progressive proportion power at HR frequency 20% 80% All variables restored rewarming groups We conclude that natriuresis diuresis consequence nephron reabsorption, reduced osmolality possibly patterning In response modified haemodynamics and/or hormonal influences induced minimize hypothermic stress function.