Hydrophobic pinning with copper nanowhiskers leads to bactericidal properties

摘要: The considerable morbidity associated with hospitalized patients and clinics in developed countries due to biofilm formation on biomedical implants surgical instruments is a heavy economic burden. An alternative chemically treated surfaces for bactericidal activity started emerging from micro/nanoscale topographical cues the last decade. Here, we demonstrate putative antibacterial surface using copper nanowhiskers deposited by molecular beam epitaxy. Furthermore, control of biological response based hydrophobic pinning water droplets Wenzel regime, causing mechanical injury cell death. Scanning electron microscopy images revealed details morphology non-contact mode laser scanning microtopography-associated quantitative parameters. Introducing bacterial culture over produces cells, leading reduction density time local medium whisker surfaces. Extended 72 hours observe inhibition scattered microcolonies significantly reduced biovolume nanowhiskers. Therefore, patterned can serve as potential antibiofilm topography-based introduce novel prospect developing mechanoresponsive nanobiomaterials reduce risk medical device biofilm-associated infections, contrary chemical leaching traditional agent.