New Microbial Secondary Metabolites Under Preclinical Development for Cancer Treatment

摘要: Numerous antitumor antibiotics have been discovered since the author initiated screening study and reported isolation of three in 1953. During last 15 years, there has great progress studies mechanisms cytotoxic actions compounds. These shown that compounds bind or react with DNA, inhibit DNA RNA synthesis, protein interfere membrane function, interact microtubules. The action therapeutic studied for some which exhibited effects on certain types human tumors. It is possible even those a life function common to normal malignant cells can exhibit against This effect may occur if tumor special characteristic, biochemical process its structure, relation compound: e.g., lack system repair damage caused by an compound; compound be distributed higher concentration than other tissues; stronger activity activate (or weaker inactivate) tissues. Therefore, showed unique selected clinical studies.