3-substituted pyrazole-5-amide compounds having antitumor activity and applications thereof
作者： 杨金玉 , 闻家辰 , 刘丹 , 赵临襄
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摘要: The invention belongs to the technical field of medicine, relates thio compounds having antitumor activity, and in particular, thio-containing 3-substituted pyrazole-5-amide pharmaceutically acceptable salts hydrates thereof a drug composition with as active ingredients, applications for preparation histone deacetylase inhibitors treatment and/or prevention cancer. compound represented by general formula I have structure described specification, wherein R1 R2 are claims specification.
参考文章(1)
Jiachen Wen, Qun Niu, Jiang Liu, Yu Bao, Jinyu Yang, Shenglin Luan, Yinbo Fan, Dan Liu, Linxiang Zhao, None, Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study Bioorganic & Medicinal Chemistry Letters. ,vol. 26, pp. 375- 379 ,(2016) , 10.1016/J.BMCL.2015.12.007