Lung transplant outcomes are influenced by severity of neutropenia and granulocyte colony-stimulating factor treatment.

作者: Laneshia Karee Tague , Davide Scozzi , Michael Wallendorf , Brian F. Gage , Alexander S. Krupnick

DOI: 10.1111/AJT.15581

关键词:

摘要: Although neutropenia is a common complication after lung transplant, its relationship with recipient outcomes remains understudied. We evaluated retrospective cohort of 228 adult transplant recipients between 2008 and 2013 to assess the association granulocyte colony-stimulating factor (GCSF) treatment outcomes. Neutropenia was categorized as mild (absolute neutrophil count 1000-1499), moderate (500-999), or severe (<500) time-varying continuous variable. Associations survival, acute rejection, chronic allograft dysfunction (CLAD) were assessed use Cox proportional hazards regression. GCSF therapy impact on CLAD, rejection development analyzed by propensity score matching. Of patients, 101 (42.1%) developed neutropenia. Recipients had higher mortality rates than those no (adjusted hazard ratio [aHR] 2.97, 95% confidence interval [CI] 1.05-8.41, P = .040), (aHR 14.508, CI 1.58-13.34, .018), 3.27, 0.89-12.01, .074) Surprisingly, associated risk for CLAD in mildly neutropenic patients 3.49, 0.93-13.04, .063), although it did decrease death severely 0.24, 0.07-0.88, .031). Taken together, our data point an important severity

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