Clinical Pharmacology and Medication-Associated Side Effects: A Review of Second-Generation Antipsychotics for Schizophrenia

摘要: Second-generation antipsychotics (SGAs) have largely replaced conventional as first-line therapy for the treatment of schizophrenia in United States. While recent evidence suggests similar efficacy with low-dose antipsychotics, much advantage favoring SGAs comes from fact that there are less extrapyramidal side effects (EPS) at effective doses these drugs. As a medication class, and exception clozapine, overall very regard to efficacy, yet heterogeneous respect receptor binding structure-activity well their effect liabilities. This paper will review clinical psychopharmacology SGAs, adverse events associated Because certain may be higher likelihood nonadherence treatment, more detailed data each EPS, weight gain metabolic abnormalities, sexual dysfunction is presented.