Absolute configuration of the isomer of fluorocitrate that inhibits aconitase
作者： William C. Stallings , Claire T. Monti , John F. Belvedere , Robert K. Preston , Jenny P. Glusker
DOI: 10.1016/0003-9861(80)90154-X
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摘要: Abstract The absolute configuration of the isomer fluorocitrate that is a strong inhibitor and activator aconitase has been determined to be 2 R , 3 as shown in Fischer perspective diagrams below. diagram Perspective This described by Dummel Kun (1969, J. Biol. Chem. 244 2966) defined (−)- erythro -fluorocitrate them. We report here structural studies mirror image (enantiomer) this isomer. Crystals complex diethyl ester (+)- with (−)-methylbenzylamine were studied X-ray diffraction techniques. Since already experimentally, (+)-erythro thereby established. noninhibitory enzyme aconitase, while its racemate powerful inhibitor. Thus it proved formed from fluoroacetyl-CoA citrate synthase, inhibits
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