The consumption of a bread enriched with dietary fibre and l-carnitine improves glucose homoeostasis and insulin sensitivity in patients with metabolic syndrome

摘要: Abstract The aim of this study was to evaluate the efficacy a bakery product enriched with dietary fibre and l -carnitine in countering glucose homoeostasis insulin sensitivity patients without MetS. This 12-week, double-blind, randomized placebo-controlled trial employing fifty-four subjects (28 MetS 26 MetS). After one month (run-in period), were divided into two intervention groups: received (5.59 g soluble 9.49 g insoluble fibre) plus 2325 mg bread (n = 26) other placebo (n = 28). Anthropometric measurements, biochemical parameters inflammatory markers LDL subfractions analysed before after intervention. Patients who exhibited significant decrease (12.4%), C-peptide (8.9%), HOMA-IR index (14.8%) percentage small dense LDL. In addition, correlation found between change baseline levels (r = −0.471; p = 0.017). No changes detected either lipid profile or at any point experimental period. conclusion, supplementation improves hydrocarbonated metabolism resistance, leading healthier atherogenic registered on clinicaltrial.gov under number NCT02281253 .