Elevated ratio of acylated to unacylated ghrelin in children and young adults with Prader–Willi syndrome

摘要: Prader–Willi syndrome (PWS) is characterized by a switch from failure to thrive excessive weight gain and hyperphagia in early childhood. Hyperghrelinemia may be involved the underlying mechanisms of switch. The purpose this study evaluate acylated ghrelin (AG) unacylated (UAG) levels PWS investigate their associations with hyperphagia. This cross-sectional clinical conducted three expert centers Netherlands France. Levels AG UAG AG/UAG ratio were determined 138 patients (0.2–29.4 years) compared 50 age-matched obese subjects (4.3–16.9 years) 39 healthy controls (0.8–28.6 years). AEBSF was used inhibit deacylation AG. As group, had higher but similar as (AG 129.1 vs 82.4 pg/ml, p = 0.016; 135.3 157.3 pg/ml, resp.), resulting significantly (1.00 0.61, p = 0.001, resp.). Obese lower than (40.3 35.3 pg/ml, also high (1.16). reason for was, however, completely different, very low UAG. without or controls, contrast those and/or who an elevated ratio. seems coincide increase ratio, even prior start